Retinol 0,3%

100 Uses

Retinol is a powerful antiaging ingredient that helps reduce the appearance of fine lines, wrinkles, and uneven skin tone. It stimulates collagen production and accelerates cell renewal, revealing smoother and brighter skin. This version is our starter concentration of 0,3%.

Refill type: Actives (100 uses)


Targets: Signs of Aging, Dryness, Textural Irregularities, Uneven Skin Tone, Acne Prone-Skin, Wrinkles and Fine lines

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- Visibly reduces wrinkles and fine lines
- Skin looks firmer and smoother
- Smoothes the skin
- Visibly reduces blemishes and evens skin tone
- Minimizes the appearance of pores
- Visibly improves acne-prone skin
- Controls oil
- Antioxidant

More information about this active ingredient benefits in the “Detailed info” section.

Retinol (Retinyl Palmitate): a stable version of Retinol, especially suitable for sensitive skin people.

Ingredients (INCI)

Water (Aqua), Coco-caprylate, Ammonium Acryloyldimethyltaurate/VP Copolymer, Retinyl palmitate, Tocopherol, Phytic Acid, Phenoxyethanol, Ethylhexylglycerin.

Note: We continuously innovate to improve the quality of our formulas. Due to this, this ingredient list may differ from the one in the box of the products depending on time and region of your purchase.



Day & Night

Sunscreen is recommended during the day.

How: introduce it into the superior compartment of your Device to add its benefits to your personalized skincare.

Remember: your personalized skincare is made from 1 base and up to 4 actives.

pH ~6.5​

Sensitive Skin: Medium Compatibility

Dermatologically tested

Pregnancy & Breastfeeding





Discover your base and actives
Take our skin quiz

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Product Details

Data sheet

Fine lines & Wrinkles
Other features
No parabens

Detailed Info

Retinol is also known as Vitamin A, It is the best antiaging active ingredient known to science and the most appreciated by aesthetic professionals. It works by stimulating cell turnover and collagen production, resulting in smoother, brighter, and firmer skin. 

If you are looking for an antiaging-focused active ingredient, and you do not have very sensitive skin, this is the best anti-aging active ingredient you can use. 

· 0,3% is our starter concentration.

· 2% is for those with more than 8 weeks of retinol use.

This formula is powered by our recognized Lesielle's Isolated Formulation.

Some of the benefits of using this Active refill in your custom skincare system:

- Wrinkles and fine lines: reduce the appearance of fine lines and wrinkles by plumping the skin and enhancing its elasticity.

- Skin firmness: restore the elasticity and resilience of your skin, making it look firmer and more youthful.

- Acne-prone skin: unclog pores and prevent breakouts by reducing the buildup of dead skin cells.

- Uneven skin tone and Pigmentation correction: fade hyperpigmentation and even out skin tone by accelerating the shedding of pigmented cells.

- Skin Texture: improves the texture of your skin by gently exfoliating the dead skin cells and revealing a smoother and softer layer underneath.

- Pore minimization: shrinks the size of your pores by tightening the skin and preventing excess oil production.

- Oil control: regulate the sebum and oil production of your skin, keeping it balanced and hydrated without making it greasy or shiny.

- Antioxidant protection: protect your skin from free radical damage and environmental stressors that can cause premature aging

You can select your active ingredients in 2 ways:

Option 1 (recommended), Take our quiz. This is the most advanced solution because it takes into account multiple factors like your lifestyle, concerns, skin type, and even active ingredient synergies.

Option 2, Select yourself. If you have some experience with skincare, you may like to decide by yourself. In this case, consider reading each active ingredient product page to get supplementary information about its properties. 
If you are starting in skincare but you like a DIY custom skincare approach, we have created a decision-tree guide to orientate you: Actives Selection Guide.pdf

NOTE: This decision tree is a simplified selection process approach. If you want the best results, we recommend you do our quiz or study the properties of the active ingredient and select the ones that, in combination (each active can have multiple effects), address your concerns in the most effective and complete way.

When to Use


Day & Night
Sunscreen is recommended during the day.


- Gradual Introduction: the 0,3% refill is designed as an introductory Retinol Concentration. Increase to the 2% concentration refill after 8 weeks of use or as your skin tolerates.

- Sun Protection: Due to the potential increase in skin sensitivity, always use sunscreen during the day, even on cloudy days, while using retinol products.

Step 1: Cleanse your skin (ideally with a non-ionic cleanser)

Step 2: Create a single dose and apply your freshly-made custom skincare.

Step 3: Apply sunscreen if required. Try to use an oil-free sunscreen to avoid adding extra oils to your skin (your base has already provided the correct amount).

All of Lesielle's products undergo dermatological testing to ensure their safety. However, since each person's skin is unique, it is always recommended to perform a patch test before using a new active ingredient in your customized skincare system. This is especially important if you have sensitive skin. Patch tests are a simple way to ensure that your skin does not have any adverse reactions to a new product.

Here's how to perform the patch test:

1. Apply a small amount of the product to your forearm.

2. Wait for 24 hours.

3. If you experience any redness, irritation, or burning sensation during the test, discontinue the use of the product and switch to an alternative solution.

Efficacy Studies from Independent Institutions

Reduces Wrinkles and Expression Lines

Skin Looks Firmer and Smoother

Visibly Reduces Spots


Scientifically proven, customer approved

Product Reviews / Q&A

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All actives contain 6ml of hyper-connected active (x10 times a standard concentrated serum), and have a minimum duration of 100 uses.

Of course, the bases and actives can be removed, stored and used again for 12 months.

Although this can happen in traditional cosmetics, with Lesielle you do not have this problem. This is because the active ingredients are mixed right at the moment of application and therefore do not have time to interact with each other. This is one of the major advantages of the isolated formulation. The only thing we do not recommend is to use the same ingredient twice or to combine two exfoliating actives (range imperfections) to avoid an action that is too powerful for the skin. In addition, you will have to take into account, but this is something to be learned by each person, which ingredients your skin tolerates.

Although all our actives have passed dermatological control individually, due to their high concentration, our recommendation is that you always mix the actives with a base cream in at least a 1:2 mixture.

We must begin by clarifying that there are no active ingredients that are compatible or not with sensitive skin, since it can react to any active ingredient, no matter how mild it may be. What we can say is that there are active ingredients that are more or less likely to be compatible.

You can find the degree of compatibility with sensitive skin in the data sheet of each active ingredient. In addition, you can filter in the category of active ingredients by their expected "compatibility" and, if you are in a physical store, you will find it indicated on their packaging or corresponding box.

The main properties are those in which the active ingredient is most effective. Secondary properties are properties that, as their name indicates, are also present, but are not the most outstanding properties of the active ingredient.

We recommend always testing each active and each base separately (especially on very reactive skin) to ensure that each of the elements are compatible with the skin on which they are to be used.

Lesielle recommends the following testing process:

First, test a base with each active separately. Apply to a sensitive area of the skin (behind the earlobe or on the inside of the forearm) and wait 48h to confirm good compatibility.

Then, once the actives have been found to be compatible individually, we should test their incremental mixing, increasing the number of combined actives as follows waiting after each test 48h.


Being a base B and the actives we want to test A1, A2 and A3:

B + A1 / B + A2 / B + A3.

B + A1 + A2

B + A1 + A2 + A3

At Lesielle we value the suggestions of our customers. Please write to us in our contact area so that we can take it into account for future releases.

Powered by Isolated Formulation™

Our innovative Isolated Formulation™ process allows us to formulate actives in their ideal medium, preserving their stability and efficacy. This technique also allows us to achieve up to 10x higher concentration than traditional skincare, ensuring you get the most out of your ingredients at every moment.

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Complete your custom skin care system

Moisturize, nourish, and condition your skin with premium oils and humectants. Choose a base that best matches to your skin type and desired  moisturization level

Customize your treatment and target specific concerns. Lesielle refills contain up to 10x the highest concentrated active ingredients powered by Isolated Formulation ™ and protected by airless technology.

Get personalized skincare at the touch of a button. Place the base and up to 4 actives in your device and make a fresh dose of face cream when you need it!


Don't you know what Base and Actives you need?
Do not worry. Take our skin quiz.

Not sure which actives to pick? We’re here to help.

The skincare system for an ever evolving skin, using recognized active ingredients with scientifically proven efficacy to create treatment tailored to each day's State of Skin. 

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