Actives icons step of Lesielle customized skincare system


(Treatment refills)

Add custom skincare treatments to your Lesielle system. Target specific skincare concerns and achieve your goals through our collection of high performing refills powered by Isolated Formulation.

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Vitamin C 20%

Vitamin C is a powerful antioxidant that brightens and evens out skin tone. It also helps to visibly reduce sunspots and protect your skin from environmental damage and signs of aging. A superior formula with 20% pure...
Niacinamide is a powerful and multifunctional skincare ingredient that can improve your skin's appearance in multiple ways. It helps to even the skin tone and visibly reduce redness, sunspots, and pore size while...
Hyaluronic Acid is a natural molecule that can hold up to 1000 times its weight in water, making it ideal for dry or dehydrated skin. It restores moisture, prevents flaking, and plumps the skin, giving you a youthful...
Salicylic acid is an exfoliant that effectively unclogs pores and removes dead skin. This makes it the top 1 exfoliant for combination, oily or acne-prone skin. Use salicylic acid for a smoother and clearer...
Vitamin E is a powerful natural antioxidant that protects your skin from environmental damage and premature aging. It also helps to nourish and hydrate your skin, leaving it soft and smooth. This formula combines two...

Retinol 2%

Retinol is a powerful antiaging ingredient that helps reduce the appearance of fine lines, wrinkles, and uneven skin tone. It stimulates collagen production and accelerates cell renewal, revealing smoother and...
Peptides are chains of amino acids that help your skin look younger and firmer. They stimulate collagen production, reduce wrinkles, and improve elasticity. Peptides are a powerful anti-aging ingredient, beneficial as...
Aloe vera is a natural ingredient that soothes and hydrates the skin. It has calming and antioxidant properties that can help irritated skin and visibly reduce redness. It can be used daily or occasionally to create...
An innovative complex that achieves an immediate tensor effect and temporarily reduces wrinkles. Formulated with wheat proteins, which create an invisible film that, when dried, tightens the skin instantaneously. Use...
Glycolic acid is a natural exfoliant that dissolves dead skin cells and oils, revealing a smoother and brighter complexion. If you have normal or dry skin, this is the best exfoliant for your skin to get glowing and...

Bisabolol 4%

Bisabolol is the main component of chamomile essential oil. It helps reduce redness thanks to its soothing and regenerating properties. It also has the remarkable additional benefit of increasing the effectiveness of...
Resveratrol is a powerful antioxidant that protects your skin from environmental damage, improves skin tone and calm altered skin. It's naturally found in red wine, berries. Try it for a smoother, firmer, and brighter...

Retinol 0,3%

Retinol is a powerful antiaging ingredient that helps reduce the appearance of fine lines, wrinkles, and uneven skin tone. It stimulates collagen production and accelerates cell renewal, revealing smoother and...
This exclusive formula is a combination of enzymes and plant extracts with a triple action against the effects of pollution on the skin. If you travel to or live in a polluted city, it is a highly recommended active...
Ferulic acid is a powerful antioxidant that helps against dull skin and protects from environmental damage. It also improves your skin tone and boosts the effectiveness of other antioxidants. If you are looking for...

Argan Oil 90%

Argan Oil, known as The Liquid Gold of Morocco, is a precious cosmetic oil used for centuries for its nourishing and moisturizing properties. It contains vitamin E, antioxidants, and omega fatty acids that nourish,...
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Icons of the lesielle custom skin care system

Complete your custom skin care system

Moisturize, nourish, and condition your skin with premium oils and humectants. Choose a base that best matches to your skin type and desired  moisturization level

Customize your treatment and target specific concerns. Lesielle refills contain up to 10x the highest concentrated active ingredients powered by Isolated Formulation ™ and protected by airless technology.

Get personalized skincare at the touch of a button. Place the base and up to 4 actives in your device and make a fresh dose of face cream when you need it!


Don't you know what Base and Actives you need?

Do not worry. Take our skin quiz.

FAQ. How can we help?

All actives contain 6ml of hyper-connected active (x10 times a standard concentrated serum), and have a minimum duration of 100 uses.

Of course, the bases and actives can be removed, stored and used again for 12 months.

Although this can happen in traditional cosmetics, with Lesielle you do not have this problem. This is because the active ingredients are mixed right at the moment of application and therefore do not have time to interact with each other. This is one of the major advantages of the isolated formulation. The only thing we do not recommend is to use the same ingredient twice or to combine two exfoliating actives (range imperfections) to avoid an action that is too powerful for the skin. In addition, you will have to take into account, but this is something to be learned by each person, which ingredients your skin tolerates.

Although all our actives have passed dermatological control individually, due to their high concentration, our recommendation is that you always mix the actives with a base cream in at least a 1:2 mixture.

We must begin by clarifying that there are no active ingredients that are compatible or not with sensitive skin, since it can react to any active ingredient, no matter how mild it may be. What we can say is that there are active ingredients that are more or less likely to be compatible.

You can find the degree of compatibility with sensitive skin in the data sheet of each active ingredient. In addition, you can filter in the category of active ingredients by their expected "compatibility" and, if you are in a physical store, you will find it indicated on their packaging or corresponding box.

The main properties are those in which the active ingredient is most effective. Secondary properties are properties that, as their name indicates, are also present, but are not the most outstanding properties of the active ingredient.

We recommend always testing each active and each base separately (especially on very reactive skin) to ensure that each of the elements are compatible with the skin on which they are to be used.

Lesielle recommends the following testing process:

First, test a foundation with each active separately. Apply to a sensitive area of the skin (behind the earlobe or on the inside of the forearm) and wait 48h to confirm good compatibility.

Then, once the actives have been found to be compatible individually, we should test their incremental mixing, increasing the number of combined actives as follows waiting after each test 48h.


Being a base B and the actives we want to test A1, A2 and A3:

B + A1 / B + A2 / B + A3

B + A1 + A2

B + A1 + A2 + A3

At Lesielle we highly value the suggestions of our customers. Please write to us in our contact area so we can take it into account for future releases.

The skincare system for an ever evolving skin, using recognized active ingredients with scientifically proven efficacy to create treatment tailored to each day's State of Skin. 

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