Actives icons step of Lesielle customized skincare system


(Treatment refills)

Add custom skincare treatments to your Lesielle system. Target specific skincare concerns and achieve your goals through our collection of high performing refills powered by Isolated Formulation.

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Retinol 0,3%


Up to 110 Uses

Mildly concentrated Retinol (Vitamin A) serum that targets general signs of aging. Your retinol starter concentration. Refill type: Active (treatment) Targets: Signs of Aging, Textural Irregularities, Uneven Skin Tone.

Retinol 2%


Up to 110 Uses

Highly concentrated Retinol (Vitamin A) serum that targets general signs of aging. Advanced retinol treatment.Refill type: Active (treatment)

Up to 110 Uses

"One of the most effective skincare actives targeting the signs of ageaing. Niacinamide (Vitamin B3) is highly compatible with sensitive skin,even with those affected by Rosacea."

Up to 110 Uses

Hyperconcentrated 0.2% Pure Peptides complex, that targets signs of ageing, and helps replenish and plump the pores. 10x higher concentration than other commercially available options.

Up to 110 Uses

An innovative active that promotes an immediate tensing effect and temporarily reduces wrinkles. An advanced formulation based on wheat proteins,which create an invisible film that tightens the skin instantaneously...

Up to 110 Uses

A popular and internationally recognized natural antioxidant. Vitamin E (tocopherol) helps prevent the signs of aging and protects the skin.

Up to 110 Uses

One of the most advanced and powerful natural antioxidants, found in red grape. Resveratiol is known for multipleproperties and high effectiveness.

Up to 110 Uses

A powerful antioxidant. Ferulic Acid prevents skin aging and defends it against pollution and environmental stress. Its antioxidant properties increase when exposed to ultraviolet light.

Up to 110 Uses

Salicilic Acid deeply cleanses the pores preventing breakouts. It helps exfoliate the skin, supports the natural shedding of dead cells, and reveals a fresh, healthy-looking complexion. Specially recommended for...

Up to 110 Uses

Glycolic Acic exfoliates the skin by dissolving dead skin cells and oils. It helps remove the top layer of skin cells without scrubbing and irritation. Deeply cleanses the pores preventing breakouts. Specially...

Up to 110 Uses

Naturally present in the skin, Hyaluronic Acid moisturizes and gives structure to the skin, making it softer and more flexible. Lesielle combines ""high molecular weight"" hyaluronic acid with ""low molecular weight""...

Argan Oil 90%


Up to 110 Uses

Known for its nourishing, moisturizing properties and antioxydant properties. The Argan Oil (the Liquid Gold of Morocco) is especially effective in dry skin. Use to add a hydration boost to any treatment.

Up to 110 Uses

An exclusive combination of enzymes and plant extracts that fightagainst the effects of pollution on the skin. Lesielle's Antipollutant is an ideal ingredient ti add to your mix if you live in a largecity or travel to...

Up to 110 Uses

A natural ingredient used for its cosmetic properties and care on the skin. Lesielle's Aloe Vera active includes the double ammount of elements of a pure aloe vera gel for optimum results.

Bisabolol 4%


Up to 110 Uses

The main component of chamomile essential oil. Thanks to its soothing and antiseptic properties, Bisabolol (Alfa-Bisbolol) is known for its soothing and antiinflamatory effects.
Showing 1-16 of 16 item(s)
Icons of the lesielle custom skin care system

Complete your custom skin care system

Moisturize, nourish, and condition your skin with premium oils and humectants. Choose a base that best matches to your skin type and desired  moisturization level

Customize your treatment and target specific concerns. Lesielle refills contain up to 10x the highest concentrated active ingredients powered by Isolated Formulation ™ and protected by airless technology.

Get personalized skincare at the touch of a button. Place the base and up to 4 actives in your device and make a fresh dose of face cream when you need it!


Don't you know what Base and Actives you need?

Do not worry. Take our skin quiz.

FAQ. How can we help?

All actives contain 6ml of hyper-connected active (x10 times a standard concentrated serum), and have a minimum duration of 70 uses.

Of course, the bases and actives can be removed, stored and used again for 12 months.

Although this can happen in traditional cosmetics, with Lesielle you do not have this problem. This is because the active ingredients are mixed right at the moment of application and therefore do not have time to interact with each other. This is one of the major advantages of the isolated formulation. The only thing we do not recommend is to use the same ingredient twice or to combine two exfoliating actives (range imperfections) to avoid an action that is too powerful for the skin. In addition, you will have to take into account, but this is something to be learned by each person, which ingredients your skin tolerates.

Although all our actives have passed dermatological control individually, due to their high concentration, our recommendation is that you always mix the actives with a base cream in at least a 1:2 mixture.

We must begin by clarifying that there are no active ingredients that are compatible or not with sensitive skin, since it can react to any active ingredient, no matter how mild it may be. What we can say is that there are active ingredients that are more or less likely to be compatible.

You can find the degree of compatibility with sensitive skin in the data sheet of each active ingredient. In addition, you can filter in the category of active ingredients by their expected "compatibility" and, if you are in a physical store, you will find it indicated on their packaging or corresponding box.

The main properties are those in which the active ingredient is most effective. Secondary properties are properties that, as their name indicates, are also present, but are not the most outstanding properties of the active ingredient.

We recommend always testing each active and each foundation separately (especially on very reactive skin) to ensure that each of the elements are compatible with the skin on which they are to be used.

Lesielle recommends the following testing process:

First, test a foundation with each active separately. Apply to a sensitive area of the skin (behind the earlobe or on the inside of the forearm) and wait 48h to confirm good compatibility.

Then, once the actives have been found to be compatible individually, we should test their incremental mixing, increasing the number of combined actives as follows waiting after each test 48h.


Being a base B and the actives we want to test A1, A2 and A3:

B + A1 / B + A2 / B + A3

B + A1 + A2

B + A1 + A2 + A3

At Lesielle we highly value the suggestions of our customers. Please write to us in our contact area so we can take it into account for future releases.

The skincare system for an ever evolving skin, using recognized active ingredients with scientifically proven efficacy to create treatment tailored to each day's State of Skin. 

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